Targeting SARS-CoV-2 Nsp12/Nsp8 interaction interface with approved and investigational drugs: anin silicostructure-based approach

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Mutlu, Ozal
Ugurel, Osman Mutluhan
Sariyer, Emrah
Ata, Oguz
Inci, Tugba Gul
Ugurel, Erennur
Kocer, Sinem
Turgut-Balik, Dilek
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Abstract
In this study, the Nsp12-Nsp8 complex of SARS-CoV-2 was targeted with structure-based and computer-aided drug design approach because of its vital role in viral replication. Sequence analysis of RNA-dependent RNA polymerase (Nsp12) sequences from 30,366 d
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https://doi.org/10.1080/07391102.2020.1819882
http://dspace.yeniyuzyil.edu.tr:8080/xmlui/handle/20.500.12629/2264
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